Zhao
Notes
Chlorpyrifos and its metabolites (Zhao et al. 2019) all parameters for Caucasian
Overview
| key | value |
|---|---|
| Modelled species/orgamism(s) | not specified |
| Model chemical(s) | not specified |
| Input route(s) | no routes detected |
| Time resolution | h |
| Amounts unit | umol |
| Volume unit | L |
| Number of compartments | 4 |
| Number of species | 7 |
| Number of parameters | 26 (17 external / 9 internal) |
Diagram
Compartments
| id | name | unit | model qualifier |
|---|---|---|---|
| Gut | not specified | not specified | not specified |
| Liver | not specified | not specified | not specified |
| Blood | not specified | not specified | not specified |
| Rest | not specified | not specified | not specified |
Species
| id | name | unit | model qualifier |
|---|---|---|---|
| AGut | not specified | not specified | not specified |
| ALiver | not specified | not specified | not specified |
| ABlood | not specified | not specified | not specified |
| ARest | not specified | not specified | not specified |
| ALiverMet1 | not specified | not specified | not specified |
| ALiverMet2 | not specified | not specified | not specified |
| ALiverMet3 | not specified | not specified | not specified |
Transfer equations
| id | from | to | equation |
|---|---|---|---|
| _J0 | AGut | ALiver | kabs * AGut |
| _J1 | ABlood | ALiver | QL * CBlood |
| _J2 | ALiver | ABlood | QL * (CLiver / PL) |
| _J3 | ABlood | ARest | QRest * CBlood |
| _J4 | ARest | ABlood | QRest * (CRest / PRest) |
| _J5 | ALiver | ALiverMet1 | VmaxLMet1 * (CLiver / PL) / (KmLMet1 + CLiver / PL) |
| _J6 | ALiver | ALiverMet2 | VmaxLMet2 * (CLiver / PL) / (KmLMet2 + CLiver / PL) |
| _J7 | ALiver | ALiverMet3 | VmaxLMet3 * (CLiver / PL) / (KmLMet3 + CLiver / PL) |
ODEs
\(\frac{d[\mathtt{AGut}]}{dt} = - \mathit{kabs}\cdot \mathit{AGut}\)
\(\frac{d[\mathtt{ALiver}]}{dt} = \mathit{kabs}\cdot \mathit{AGut} + \mathit{QL}\cdot \mathit{CBlood} - \mathit{QL}\cdot \frac{\mathit{CLiver}}{\mathit{PL}} - \frac{\mathit{VmaxLMet1}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet1}+\frac{\mathit{CLiver}}{\mathit{PL}}} - \frac{\mathit{VmaxLMet2}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet2}+\frac{\mathit{CLiver}}{\mathit{PL}}} - \frac{\mathit{VmaxLMet3}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet3}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
\(\frac{d[\mathtt{ABlood}]}{dt} = - \mathit{QL}\cdot \mathit{CBlood} + \mathit{QL}\cdot \frac{\mathit{CLiver}}{\mathit{PL}} - \mathit{QRest}\cdot \mathit{CBlood} + \mathit{QRest}\cdot \frac{\mathit{CRest}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{ARest}]}{dt} = \mathit{QRest}\cdot \mathit{CBlood} - \mathit{QRest}\cdot \frac{\mathit{CRest}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{ALiverMet1}]}{dt} = \frac{\mathit{VmaxLMet1}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet1}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
\(\frac{d[\mathtt{ALiverMet2}]}{dt} = \frac{\mathit{VmaxLMet2}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet2}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
\(\frac{d[\mathtt{ALiverMet3}]}{dt} = \frac{\mathit{VmaxLMet3}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet3}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
Assignment rules
| variable | assignment |
|---|---|
| VL | VLc * BW |
| VB | VBc * BW |
| VRest | 0.84 * BW - VL - VB |
| QL | QLc * QC |
| QRest | QC - QL |
| CBlood | ABlood / Blood |
| CLiver | ALiver / Liver |
| CVL | CLiver / PL |
| CRest | ARest / Rest |
Initial assignments
| variable | assignment |
|---|---|
| Liver | VL |
| Blood | VB |
| Rest | VRest |
Parameters
| id | name | unit | model qualifier |
|---|---|---|---|
| BW | not specified | not specified | not specified |
| VLc | not specified | not specified | not specified |
| VBc | not specified | not specified | not specified |
| VL | not specified | not specified | not specified |
| VB | not specified | not specified | not specified |
| VRest | not specified | not specified | not specified |
| QC | not specified | not specified | not specified |
| QLc | not specified | not specified | not specified |
| QL | not specified | not specified | not specified |
| QRest | not specified | not specified | not specified |
| PL | not specified | not specified | not specified |
| PRest | not specified | not specified | not specified |
| kabs | not specified | not specified | not specified |
| KmLMet1 | not specified | not specified | not specified |
| VmaxLMet1C | not specified | not specified | not specified |
| VmaxLMet1 | not specified | not specified | not specified |
| KmLMet2 | not specified | not specified | not specified |
| VmaxLMet2C | not specified | not specified | not specified |
| VmaxLMet2 | not specified | not specified | not specified |
| KmLMet3 | not specified | not specified | not specified |
| VmaxLMet3C | not specified | not specified | not specified |
| VmaxLMet3 | not specified | not specified | not specified |
| CBlood | not specified | not specified | not specified |
| CLiver | not specified | not specified | not specified |
| CVL | not specified | not specified | not specified |
| CRest | not specified | not specified | not specified |