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Wei

Notes


Permethrin PBK - Wei et al. 2013

Overview

key value
Modelled species/orgamism(s) not specified
Model chemical(s) not specified
Input route(s) no routes detected
Time resolution not specified
Amounts unit not specified
Volume unit not specified
Number of compartments 9
Number of species 11
Number of parameters 31 (18 external / 13 internal)

Diagram

Diagram

Compartments

id name unit model qualifier
Stomach not specified not specified not specified
Intestinal not specified not specified not specified
Liver not specified not specified not specified
Blood not specified not specified not specified
RestVC not specified not specified not specified
RestT not specified not specified not specified
Fecal not specified not specified not specified
Urine not specified not specified not specified
ExcretionCompartment not specified not specified not specified

Species

id name unit model qualifier
ASt not specified not specified not specified
AIT not specified not specified not specified
ALiver not specified not specified not specified
ABlood not specified not specified not specified
ARestT not specified not specified not specified
ARestVC not specified not specified not specified
ALiverMet not specified not specified not specified
ABloodMet not specified not specified not specified
AExcr not specified not specified not specified
AFecal not specified not specified not specified
AUrine not specified not specified not specified

Transfer equations

id from to equation
_J0 ASt AIT ksto * ASt
_J1 ASt ALiver k0 * ASt
_J2 AIT ALiver kabs * AIT
_J3 AIT AFecal kfe * AIT
_J4 ABlood ALiver QL * CBlood
_J5 ALiver ABlood QL * CLiver / PL
_J6 ABlood ARestVC QRest * CBlood
_J7 ARestVC ABlood QRest * CRestVC / PRest
_J8 ARestT ARestVC PSARest * CRestT / PRest
_J9 ARestVC ARestT PSARest * CRestVC
_J10 ALiver AExcr CLintL * CLiver / PL
_J11 ABlood AExcr CLintB * CBlood
_J12 AExcr AUrine kur * AExcr

ODEs

\(\frac{d[\mathtt{ASt}]}{dt} = - \mathit{ksto}\cdot \mathit{ASt} - \mathit{k0}\cdot \mathit{ASt}\)

\(\frac{d[\mathtt{AIT}]}{dt} = \mathit{ksto}\cdot \mathit{ASt} - \mathit{kabs}\cdot \mathit{AIT} - \mathit{kfe}\cdot \mathit{AIT}\)

\(\frac{d[\mathtt{ALiver}]}{dt} = \mathit{k0}\cdot \mathit{ASt} + \mathit{kabs}\cdot \mathit{AIT} + \mathit{QL}\cdot \mathit{CBlood} - \frac{\mathit{QL}\cdot \mathit{CLiver}}{\mathit{PL}} - \frac{\mathit{CLintL}\cdot \mathit{CLiver}}{\mathit{PL}}\)

\(\frac{d[\mathtt{ABlood}]}{dt} = - \mathit{QL}\cdot \mathit{CBlood} + \frac{\mathit{QL}\cdot \mathit{CLiver}}{\mathit{PL}} - \mathit{QRest}\cdot \mathit{CBlood} + \frac{\mathit{QRest}\cdot \mathit{CRestVC}}{\mathit{PRest}} - \mathit{CLintB}\cdot \mathit{CBlood}\)

\(\frac{d[\mathtt{ARestT}]}{dt} = - \frac{\mathit{PSARest}\cdot \mathit{CRestT}}{\mathit{PRest}} + \mathit{PSARest}\cdot \mathit{CRestVC}\)

\(\frac{d[\mathtt{ARestVC}]}{dt} = \mathit{QRest}\cdot \mathit{CBlood} - \frac{\mathit{QRest}\cdot \mathit{CRestVC}}{\mathit{PRest}} + \frac{\mathit{PSARest}\cdot \mathit{CRestT}}{\mathit{PRest}} - \mathit{PSARest}\cdot \mathit{CRestVC}\)

\(\frac{d[\mathtt{AExcr}]}{dt} = \frac{\mathit{CLintL}\cdot \mathit{CLiver}}{\mathit{PL}} + \mathit{CLintB}\cdot \mathit{CBlood} - \mathit{kur}\cdot \mathit{AExcr}\)

\(\frac{d[\mathtt{AFecal}]}{dt} = \mathit{kfe}\cdot \mathit{AIT}\)

\(\frac{d[\mathtt{AUrine}]}{dt} = \mathit{kur}\cdot \mathit{AExcr}\)

Assignment rules

variable assignment
RestVC VRest * BVRest
RestT (1 - BVRest) * VRest
VB VBc * BW
VL VLc * BW
VRest 0.84 * BW - VL - VB
BVRest BVRestC * VRest
QC QCc * pow(BW, 0.75)
QL QLc * QC
QRest QC - QL
PSARest PSARestc * VRest
CIT AIT / Intestinal
CLiver ALiver / Liver
CBlood ABlood / Blood
CRestT ARestT / RestT
CRestVC ARestVC / RestVC

Initial assignments

variable assignment
Liver VL
Blood VB
CLintL CLintBC * pow(BW, 0.75)
CLintB CLintBC * (VB / 2)

Parameters

id name unit model qualifier
BW not specified not specified not specified
VBc not specified not specified not specified
VLc not specified not specified not specified
VB not specified not specified not specified
VL not specified not specified not specified
VRest not specified not specified not specified
BVRestC not specified not specified not specified
BVRest not specified not specified not specified
QCc not specified not specified not specified
QC not specified not specified not specified
QLc not specified not specified not specified
QL not specified not specified not specified
QRest not specified not specified not specified
PL not specified not specified not specified
PRest not specified not specified not specified
PSARestc not specified not specified not specified
PSARest not specified not specified not specified
ksto not specified not specified not specified
kabs not specified not specified not specified
k0 not specified not specified not specified
kfe not specified not specified not specified
kur not specified not specified not specified
CLintLC not specified not specified not specified
CLintL not specified not specified not specified
CLintBC not specified not specified not specified
CLintB not specified not specified not specified
CIT not specified not specified not specified
CLiver not specified not specified not specified
CBlood not specified not specified not specified
CRestT not specified not specified not specified
CRestVC not specified not specified not specified