Tonnelier
Notes
Tonnelier et al 2012 - example Chlorpyrifos
Overview
| key | value |
|---|---|
| Modelled species/orgamism(s) | not specified |
| Model chemical(s) | not specified |
| Input route(s) | no routes detected |
| Time resolution | not specified |
| Amounts unit | not specified |
| Volume unit | not specified |
| Number of compartments | 5 |
| Number of species | 6 |
| Number of parameters | 17 (11 external / 6 internal) |
Diagram
Compartments
| id | name | unit | model qualifier |
|---|---|---|---|
| AbsorptionCompartment | not specified | not specified | not specified |
| PV | not specified | not specified | not specified |
| Liver | not specified | not specified | not specified |
| SystCompartment | not specified | not specified | not specified |
| RenalExcretion | not specified | not specified | not specified |
Species
| id | name | unit | model qualifier |
|---|---|---|---|
| AAbsComp | not specified | not specified | not specified |
| APV | not specified | not specified | not specified |
| ALiver | not specified | not specified | not specified |
| ALiverMet | not specified | not specified | not specified |
| ASysComp | not specified | not specified | not specified |
| ARenalEx | not specified | not specified | not specified |
Transfer equations
| id | from | to | equation |
|---|---|---|---|
| _J0 | AAbsComp | APV | kabs * AAbsComp |
| _J1 | APV | ALiver | QPV * CPV |
| _J2 | ASysComp | APV | QPV * CSysComp |
| _J3 | ASysComp | ALiver | QHA * CSysComp |
| _J4 | ALiver | ASysComp | (QPV + QHA) * CLiver |
| _J5 | ALiver | ALiverMet | CL * CLiver |
| _J6 | ASysComp | ARenalEx | CLR * CSysComp |
ODEs
\(\frac{d[\mathtt{AAbsComp}]}{dt} = - \mathit{kabs}\cdot \mathit{AAbsComp}\)
\(\frac{d[\mathtt{APV}]}{dt} = \mathit{kabs}\cdot \mathit{AAbsComp} - \mathit{QPV}\cdot \mathit{CPV} + \mathit{QPV}\cdot \mathit{CSysComp}\)
\(\frac{d[\mathtt{ALiver}]}{dt} = \mathit{QPV}\cdot \mathit{CPV} + \mathit{QHA}\cdot \mathit{CSysComp} - (\mathit{QPV}+\mathit{QHA})\cdot \mathit{CLiver} - \mathit{CL}\cdot \mathit{CLiver}\)
\(\frac{d[\mathtt{ALiverMet}]}{dt} = \mathit{CL}\cdot \mathit{CLiver}\)
\(\frac{d[\mathtt{ASysComp}]}{dt} = - \mathit{QPV}\cdot \mathit{CSysComp} - \mathit{QHA}\cdot \mathit{CSysComp} + (\mathit{QPV}+\mathit{QHA})\cdot \mathit{CLiver} - \mathit{CLR}\cdot \mathit{CSysComp}\)
\(\frac{d[\mathtt{ARenalEx}]}{dt} = \mathit{CLR}\cdot \mathit{CSysComp}\)
Assignment rules
| variable | assignment |
|---|---|
| AbsorptionCompartment | 1 |
| PV | VPV |
| Liver | VL |
| SystCompartment | VD |
| RenalExcretion | 1 |
| VL | VLc * BW |
| QH | QPV + QHA |
| CL | QH * fu * CLHint / (QH + fu * CLHint) |
| CPV | APV / PV |
| CLiver | ALiver / Liver |
| CSysComp | ASysComp / SystCompartment |
Parameters
| id | name | unit | model qualifier |
|---|---|---|---|
| VPV | not specified | not specified | not specified |
| BW | not specified | not specified | not specified |
| VLc | not specified | not specified | not specified |
| VL | not specified | not specified | not specified |
| VD | not specified | not specified | not specified |
| QPV | not specified | not specified | not specified |
| QHA | not specified | not specified | not specified |
| QH | not specified | not specified | not specified |
| FA | not specified | not specified | not specified |
| kabs | not specified | not specified | not specified |
| CLHint | not specified | not specified | not specified |
| fu | not specified | not specified | not specified |
| CL | not specified | not specified | not specified |
| CLR | not specified | not specified | not specified |
| CPV | not specified | not specified | not specified |
| CLiver | not specified | not specified | not specified |
| CSysComp | not specified | not specified | not specified |