Mallick
Notes
Pyrethroids Mallick et al 2020.
Overview
| key | value |
|---|---|
| Modelled species/orgamism(s) | not specified |
| Model chemical(s) | not specified |
| Input route(s) | no routes detected |
| Time resolution | not specified |
| Amounts unit | not specified |
| Volume unit | not specified |
| Number of compartments | 6 |
| Number of species | 7 |
| Number of parameters | 36 (18 external / 18 internal) |
Diagram
Compartments
| id | name | unit | model qualifier |
|---|---|---|---|
| Lumen | not specified | not specified | not specified |
| Gut | not specified | not specified | not specified |
| Liver | not specified | not specified | not specified |
| Plasma | not specified | not specified | not specified |
| RestPlasma | not specified | not specified | not specified |
| RestTissue | not specified | not specified | not specified |
Species
| id | name | unit | model qualifier |
|---|---|---|---|
| ALumen | not specified | not specified | not specified |
| AGut | not specified | not specified | not specified |
| ALiver | not specified | not specified | not specified |
| APlasma | not specified | not specified | not specified |
| ARestPlasma | not specified | not specified | not specified |
| ARestTissue | not specified | not specified | not specified |
| ALiverMet1 | not specified | not specified | not specified |
Transfer equations
| id | from | to | equation |
|---|---|---|---|
| _J0 | ALumen | AGut | kabs * (1 - LymphAbs) * ALumen |
| _J1 | ALumen | APlasma | kabs * LymphAbs * ALumen |
| _J2 | AGut | ALiver | QGut * Free * CGut / PG |
| _J3 | APlasma | AGut | QGut * CPlasma |
| _J4 | APlasma | ALiver | QL * CPlasma |
| _J5 | ALiver | APlasma | (QL + QGut) * Free * CLiver / PL |
| _J6 | APlasma | ARestPlasma | QRest * CPlasma |
| _J7 | ARestPlasma | APlasma | QRest * Free * CRestPlasma / PRest |
| _J8 | ARestPlasma | ARestTissue | PASP * Free * CRestPlasma / PRest |
| _J9 | ARestTissue | ARestPlasma | PASP * Free * CRestTissue |
| _J10 | ALiver | ALiverMet1 | CL1 * (Free * CLiver / SF) |
ODEs
\(\frac{d[\mathtt{ALumen}]}{dt} = - \mathit{kabs}\cdot (1-\mathit{LymphAbs})\cdot \mathit{ALumen} - \mathit{kabs}\cdot \mathit{LymphAbs}\cdot \mathit{ALumen}\)
\(\frac{d[\mathtt{AGut}]}{dt} = \mathit{kabs}\cdot (1-\mathit{LymphAbs})\cdot \mathit{ALumen} - \frac{\mathit{QGut}\cdot \mathit{Free}\cdot \mathit{CGut}}{\mathit{PG}} + \mathit{QGut}\cdot \mathit{CPlasma}\)
\(\frac{d[\mathtt{ALiver}]}{dt} = \frac{\mathit{QGut}\cdot \mathit{Free}\cdot \mathit{CGut}}{\mathit{PG}} + \mathit{QL}\cdot \mathit{CPlasma} - \frac{(\mathit{QL}+\mathit{QGut})\cdot \mathit{Free}\cdot \mathit{CLiver}}{\mathit{PL}} - \mathit{CL1}\cdot \frac{\mathit{Free}\cdot \mathit{CLiver}}{\mathit{SF}}\)
\(\frac{d[\mathtt{APlasma}]}{dt} = \mathit{kabs}\cdot \mathit{LymphAbs}\cdot \mathit{ALumen} - \mathit{QGut}\cdot \mathit{CPlasma} - \mathit{QL}\cdot \mathit{CPlasma} + \frac{(\mathit{QL}+\mathit{QGut})\cdot \mathit{Free}\cdot \mathit{CLiver}}{\mathit{PL}} - \mathit{QRest}\cdot \mathit{CPlasma} + \frac{\mathit{QRest}\cdot \mathit{Free}\cdot \mathit{CRestPlasma}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{ARestPlasma}]}{dt} = \mathit{QRest}\cdot \mathit{CPlasma} - \frac{\mathit{QRest}\cdot \mathit{Free}\cdot \mathit{CRestPlasma}}{\mathit{PRest}} - \frac{\mathit{PASP}\cdot \mathit{Free}\cdot \mathit{CRestPlasma}}{\mathit{PRest}} + \mathit{PASP}\cdot \mathit{Free}\cdot \mathit{CRestTissue}\)
\(\frac{d[\mathtt{ARestTissue}]}{dt} = \frac{\mathit{PASP}\cdot \mathit{Free}\cdot \mathit{CRestPlasma}}{\mathit{PRest}} - \mathit{PASP}\cdot \mathit{Free}\cdot \mathit{CRestTissue}\)
\(\frac{d[\mathtt{ALiverMet1}]}{dt} = \mathit{CL1}\cdot \frac{\mathit{Free}\cdot \mathit{CLiver}}{\mathit{SF}}\)
Assignment rules
| variable | assignment |
|---|---|
| Lumen | 1 |
| VL | VLc * BW |
| VBlood | VBloodc * BW |
| VGut | VGutc * BW |
| VRest | 0.84 * BW - VL - VBlood - VGut |
| VRestTissue | VRest * FTB |
| VRestPlasma | VRest * (1 - FTB) |
| QPlasma | QC * (1 - Htc) |
| QL | QLhc * QPlasma |
| QGut | QGutc * QPlasma |
| QRest | QPlasma - QL - QGut |
| PASP | PASPc * pow(BW, 0.75) |
| CL1 | CL1C * BW |
| CGut | AGut / Gut |
| CLiver | ALiver / Liver |
| CPlasmaTotal | APlasma / Plasma |
| CPlasma | CPlasmaTotal * Free |
| CRestPlasma | ARestPlasma / RestPlasma |
| CRestTissue | ARestTissue / RestTissue |
Initial assignments
| variable | assignment |
|---|---|
| Gut | VGut |
| Liver | VL |
| Plasma | VBlood |
| RestPlasma | VRestPlasma |
| RestTissue | VRestTissue |
Parameters
| id | name | unit | model qualifier |
|---|---|---|---|
| BW | not specified | not specified | not specified |
| VLc | not specified | not specified | not specified |
| VBloodc | not specified | not specified | not specified |
| VGutc | not specified | not specified | not specified |
| VL | not specified | not specified | not specified |
| VBlood | not specified | not specified | not specified |
| VGut | not specified | not specified | not specified |
| FTB | not specified | not specified | not specified |
| VRest | not specified | not specified | not specified |
| VRestTissue | not specified | not specified | not specified |
| VRestPlasma | not specified | not specified | not specified |
| Htc | not specified | not specified | not specified |
| QC | not specified | not specified | not specified |
| QPlasma | not specified | not specified | not specified |
| QGutc | not specified | not specified | not specified |
| QLhc | not specified | not specified | not specified |
| QL | not specified | not specified | not specified |
| QGut | not specified | not specified | not specified |
| QRest | not specified | not specified | not specified |
| PL | not specified | not specified | not specified |
| PG | not specified | not specified | not specified |
| PRest | not specified | not specified | not specified |
| Free | not specified | not specified | not specified |
| kabs | not specified | not specified | not specified |
| LymphAbs | not specified | not specified | not specified |
| PASPc | not specified | not specified | not specified |
| PASP | not specified | not specified | not specified |
| CL1C | not specified | not specified | not specified |
| CL1 | not specified | not specified | not specified |
| SF | not specified | not specified | not specified |
| CGut | not specified | not specified | not specified |
| CLiver | not specified | not specified | not specified |
| CPlasmaTotal | not specified | not specified | not specified |
| CPlasma | not specified | not specified | not specified |
| CRestPlasma | not specified | not specified | not specified |
| CRestTissue | not specified | not specified | not specified |