Godin
Notes
Delamethrin PBK - Godin et al. 2010
Overview
| key | value |
|---|---|
| Modelled species/orgamism(s) | not specified |
| Model chemical(s) | not specified |
| Input route(s) | no routes detected |
| Time resolution | not specified |
| Amounts unit | not specified |
| Volume unit | not specified |
| Number of compartments | 8 |
| Number of species | 10 |
| Number of parameters | 34 (18 external / 16 internal) |
Diagram
Compartments
| id | name | unit | model qualifier |
|---|---|---|---|
| Stomach | not specified | not specified | not specified |
| Intestinal | not specified | not specified | not specified |
| LiverVC | not specified | not specified | not specified |
| LiverIC | not specified | not specified | not specified |
| Blood | not specified | not specified | not specified |
| RestVC | not specified | not specified | not specified |
| RestIC | not specified | not specified | not specified |
| Fecal | not specified | not specified | not specified |
Species
| id | name | unit | model qualifier |
|---|---|---|---|
| ASt | not specified | not specified | not specified |
| AIT | not specified | not specified | not specified |
| ALiverVC | not specified | not specified | not specified |
| ALiverIC | not specified | not specified | not specified |
| ABlood | not specified | not specified | not specified |
| ARestVC | not specified | not specified | not specified |
| ARestIC | not specified | not specified | not specified |
| ALiverMet | not specified | not specified | not specified |
| ABloodMet | not specified | not specified | not specified |
| AFecal | not specified | not specified | not specified |
Transfer equations
| id | from | to | equation |
|---|---|---|---|
| _J0 | ASt | AIT | ksto * ASt |
| _J1 | AIT | ALiverVC | kabs * AIT |
| _J2 | AIT | AFecal | kfe * AIT |
| _J3 | ABlood | ALiverVC | QL * CBlood |
| _J4 | ALiverVC | ABlood | QL * CLiverVC / PL |
| _J5 | ABlood | ARestVC | QRest * CBlood |
| _J6 | ARestVC | ABlood | QRest * CRestVC / PRest |
| _J7 | ALiverVC | ALiverIC | PSAL * CLiverVC |
| _J8 | ALiverIC | ALiverVC | PSAL * CLiverIC / PL |
| _J9 | ARestVC | ARestIC | PSARest * CRestVC |
| _J10 | ARestIC | ARestVC | PSARest * CRestIC / PRest |
| _J11 | ALiverIC | ALiverMet | CLint * CLiverIC / PL |
| _J12 | ABlood | ABloodMet | CLintB * CBlood |
ODEs
\(\frac{d[\mathtt{ASt}]}{dt} = - \mathit{ksto}\cdot \mathit{ASt}\)
\(\frac{d[\mathtt{AIT}]}{dt} = \mathit{ksto}\cdot \mathit{ASt} - \mathit{kabs}\cdot \mathit{AIT} - \mathit{kfe}\cdot \mathit{AIT}\)
\(\frac{d[\mathtt{ALiverVC}]}{dt} = \mathit{kabs}\cdot \mathit{AIT} + \mathit{QL}\cdot \mathit{CBlood} - \frac{\mathit{QL}\cdot \mathit{CLiverVC}}{\mathit{PL}} - \mathit{PSAL}\cdot \mathit{CLiverVC} + \frac{\mathit{PSAL}\cdot \mathit{CLiverIC}}{\mathit{PL}}\)
\(\frac{d[\mathtt{ALiverIC}]}{dt} = \mathit{PSAL}\cdot \mathit{CLiverVC} - \frac{\mathit{PSAL}\cdot \mathit{CLiverIC}}{\mathit{PL}} - \frac{\mathit{CLint}\cdot \mathit{CLiverIC}}{\mathit{PL}}\)
\(\frac{d[\mathtt{ABlood}]}{dt} = - \mathit{QL}\cdot \mathit{CBlood} + \frac{\mathit{QL}\cdot \mathit{CLiverVC}}{\mathit{PL}} - \mathit{QRest}\cdot \mathit{CBlood} + \frac{\mathit{QRest}\cdot \mathit{CRestVC}}{\mathit{PRest}} - \mathit{CLintB}\cdot \mathit{CBlood}\)
\(\frac{d[\mathtt{ARestVC}]}{dt} = \mathit{QRest}\cdot \mathit{CBlood} - \frac{\mathit{QRest}\cdot \mathit{CRestVC}}{\mathit{PRest}} - \mathit{PSARest}\cdot \mathit{CRestVC} + \frac{\mathit{PSARest}\cdot \mathit{CRestIC}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{ARestIC}]}{dt} = \mathit{PSARest}\cdot \mathit{CRestVC} - \frac{\mathit{PSARest}\cdot \mathit{CRestIC}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{ALiverMet}]}{dt} = \frac{\mathit{CLint}\cdot \mathit{CLiverIC}}{\mathit{PL}}\)
\(\frac{d[\mathtt{ABloodMet}]}{dt} = \mathit{CLintB}\cdot \mathit{CBlood}\)
\(\frac{d[\mathtt{AFecal}]}{dt} = \mathit{kfe}\cdot \mathit{AIT}\)
Assignment rules
| variable | assignment |
|---|---|
| LiverIC | VL - BVLiver |
| RestIC | VRest - BVRest |
| VB | VBc * BW |
| VL | VLc * BW |
| VRest | 0.84 * BW - VL - VB |
| BVLiver | BVLiverC * VL |
| BVRest | BVRestC * VRest |
| QC | QCc * pow(BW, 0.75) |
| QL | QLc * QC |
| QRest | QC - QL |
| PSAL | PSALc * VL |
| PSARest | PSARestc * VRest |
| CIT | AIT / Intestinal |
| CLiverVC | ALiverVC / LiverVC |
| CLiverIC | ALiverIC / LiverIC |
| CBlood | ABlood / Blood |
| CRestVC | ARestVC / RestVC |
| CRestIC | ARestIC / RestIC |
Initial assignments
| variable | assignment |
|---|---|
| LiverVC | BVLiver |
| Blood | VB |
| RestVC | BVRest |
| CLint | CLintC * BW |
| CLintB | CLintBC * (VB / 2) |
Parameters
| id | name | unit | model qualifier |
|---|---|---|---|
| BW | not specified | not specified | not specified |
| VBc | not specified | not specified | not specified |
| VLc | not specified | not specified | not specified |
| VB | not specified | not specified | not specified |
| VL | not specified | not specified | not specified |
| VRest | not specified | not specified | not specified |
| BVLiverC | not specified | not specified | not specified |
| BVLiver | not specified | not specified | not specified |
| BVRestC | not specified | not specified | not specified |
| BVRest | not specified | not specified | not specified |
| QCc | not specified | not specified | not specified |
| QC | not specified | not specified | not specified |
| QLc | not specified | not specified | not specified |
| QL | not specified | not specified | not specified |
| QRest | not specified | not specified | not specified |
| PL | not specified | not specified | not specified |
| PRest | not specified | not specified | not specified |
| PSALc | not specified | not specified | not specified |
| PSAL | not specified | not specified | not specified |
| PSARestc | not specified | not specified | not specified |
| PSARest | not specified | not specified | not specified |
| ksto | not specified | not specified | not specified |
| kabs | not specified | not specified | not specified |
| kfe | not specified | not specified | not specified |
| CLintC | not specified | not specified | not specified |
| CLint | not specified | not specified | not specified |
| CLintBC | not specified | not specified | not specified |
| CLintB | not specified | not specified | not specified |
| CIT | not specified | not specified | not specified |
| CLiverVC | not specified | not specified | not specified |
| CLiverIC | not specified | not specified | not specified |
| CBlood | not specified | not specified | not specified |
| CRestVC | not specified | not specified | not specified |
| CRestIC | not specified | not specified | not specified |