Mendez_Catala
Notes
Mendez-Catala, D. M., et al. (2021) Human PBK for oral absorption (administration → blood) with 7 SI boxes + Rest Parent only, perfusion-limited tissues
Overview
| key | value |
|---|---|
| Modelled species/orgamism(s) | http://purl.obolibrary.org/obo/NCBITaxon_9606 |
| Model chemical(s) | http://purl.obolibrary.org/obo/CHEBI_10106 |
| Input route(s) | no routes detected |
| Time resolution | h |
| Amounts unit | mg |
| Volume unit | L |
| Number of compartments | 14 |
| Number of species | 20 |
| Number of parameters | 87 (38 external / 49 internal) |
Diagram
Compartments
| id | name | unit | model qualifier |
|---|---|---|---|
| Stomach | Stomach compartment | L | http://purl.obolibrary.org/obo/PBPKO_00566 |
| SI1 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| SI2 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| SI3 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| SI4 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| SI5 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| SI6 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| SI7 | Small intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00472 |
| LI1 | Large intestine compartment | L | http://purl.obolibrary.org/obo/PBPKO_00474 |
| SITissue | Small intestine tissue compartment | L | not specified |
| Liver | Liver compartment | L | http://purl.obolibrary.org/obo/PBPKO_00558 |
| Blood | Blood compartment | L | http://purl.obolibrary.org/obo/PBPKO_00464 |
| Rest | Rest of body compartment | L | http://purl.obolibrary.org/obo/PBPKO_00450 |
| Feaces | Feces compartment | L | http://purl.obolibrary.org/obo/PBPKO_00555 |
Species
| id | name | unit | model qualifier |
|---|---|---|---|
| ASt | Amount in stomach | mg | not specified |
| ASI1 | Amount in small intestine | mg | not specified |
| ASI2 | Amount in small intestine | mg | not specified |
| ASI3 | Amount in small intestine | mg | not specified |
| ASI4 | Amount in small intestine | mg | not specified |
| ASI5 | Amount in small intestine | mg | not specified |
| ASI6 | Amount in small intestine | mg | not specified |
| ASI7 | Amount in small intestine | mg | not specified |
| ALI1 | Amount in large intestine | mg | not specified |
| ASITissue | Amount in small intestine tissue | mg | not specified |
| ALiver | Amount in liver | mg | http://purl.obolibrary.org/obo/PBPKO_00497 |
| ABlood | Amount in blood | mg | http://purl.obolibrary.org/obo/PBPKO_00623 |
| ARest | Amount in rest of body | mg | http://purl.obolibrary.org/obo/PBPKO_00501 |
| AFeaces | Amount in feces | mg | http://purl.obolibrary.org/obo/PBPKO_00273 |
| ASITissueMet1 | Amount of metabolite in small intestine tissue | mg | not specified |
| ALI1Met2 | Amount of metabolite in large intestine | mg | not specified |
| ALI1Met3 | Amount of metabolite in large intestine | mg | not specified |
| ALiverMet2 | Amount of metabolite in liver | mg | http://purl.obolibrary.org/obo/PBPKO_00497 |
| ALiverMet3 | Amount of metabolite in liver | mg | http://purl.obolibrary.org/obo/PBPKO_00497 |
| ALiverMet1 | Amount of metabolite in liver | mg | http://purl.obolibrary.org/obo/PBPKO_00497 |
Transfer equations
| id | from | to | equation |
|---|---|---|---|
| _J0 | ASt | ASI1 | ksto * ASt |
| _J1 | ASI1 | ASI2 | kt1 * ASI1 |
| _J2 | ASI2 | ASI3 | kt2 * ASI2 |
| _J3 | ASI3 | ASI4 | kt3 * ASI3 |
| _J4 | ASI4 | ASI5 | kt4 * ASI4 |
| _J5 | ASI5 | ASI6 | kt5 * ASI5 |
| _J6 | ASI6 | ASI7 | kt6 * ASI6 |
| _J7 | ASI7 | ALI1 | kt7 * ASI7 |
| _J8 | ASI1 | ASITissue | kabsSI1 * CSI1 |
| _J9 | ASI2 | ASITissue | kabsSI2 * CSI2 |
| _J10 | ASI3 | ASITissue | kabsSI3 * CSI3 |
| _J11 | ASI4 | ASITissue | kabsSI4 * CSI4 |
| _J12 | ASI5 | ASITissue | kabsSI5 * CSI5 |
| _J13 | ASI6 | ASITissue | kabsSI6 * CSI6 |
| _J14 | ASI7 | ASITissue | kabsSI7 * CSI7 |
| _J15 | ALI1 | ALiver | kabsLI * CLI1 |
| _J16 | ALI1 | AFeaces | kfe * ALI1 |
| _J17 | ASITissue | ALiver | QSI * CSITissue / PSI |
| _J18 | ABlood | ASITissue | QSI * CBlood |
| _J19 | ABlood | ALiver | QL * CBlood |
| _J20 | ALiver | ABlood | (QL + QSI) * CLiver / PL |
| _J21 | ABlood | ARest | QRest * CBlood |
| _J22 | ARest | ABlood | QRest * (ARest / Rest) / PRest |
| _J23 | ASITissue | ASITissueMet1 | VmaxSIMet1 * (CSITissue / PSI) / (KmSIMet1 + CSITissue / PSI) |
| _J24 | ALI1 | ALI1Met2 | VmaxLIMet2 * CLI1 / (KmLIMet2 + CLI1) |
| _J25 | ALI1 | ALI1Met3 | VmaxLIMet3 * CLI1 / (KmLIMet3 + CLI1) |
| _J26 | ALiver | ALiverMet2 | VmaxLMet2 * (CLiver / PL) / (KmLMet2 + CLiver / PL) |
| _J27 | ALiver | ALiverMet3 | VmaxLMet3 * (CLiver / PL) / (KmLMet3 + CLiver / PL) |
| _J28 | ALiver | ALiverMet1 | VmaxLMet1 * (CLiver / PL) / (KmLMet1 + CLiver / PL) |
ODEs
\(\frac{d[\mathtt{ASt}]}{dt} = - \mathit{ksto}\cdot \mathit{ASt}\)
\(\frac{d[\mathtt{ASI1}]}{dt} = \mathit{ksto}\cdot \mathit{ASt} - \mathit{kt1}\cdot \mathit{ASI1} - \mathit{kabsSI1}\cdot \mathit{CSI1}\)
\(\frac{d[\mathtt{ASI2}]}{dt} = \mathit{kt1}\cdot \mathit{ASI1} - \mathit{kt2}\cdot \mathit{ASI2} - \mathit{kabsSI2}\cdot \mathit{CSI2}\)
\(\frac{d[\mathtt{ASI3}]}{dt} = \mathit{kt2}\cdot \mathit{ASI2} - \mathit{kt3}\cdot \mathit{ASI3} - \mathit{kabsSI3}\cdot \mathit{CSI3}\)
\(\frac{d[\mathtt{ASI4}]}{dt} = \mathit{kt3}\cdot \mathit{ASI3} - \mathit{kt4}\cdot \mathit{ASI4} - \mathit{kabsSI4}\cdot \mathit{CSI4}\)
\(\frac{d[\mathtt{ASI5}]}{dt} = \mathit{kt4}\cdot \mathit{ASI4} - \mathit{kt5}\cdot \mathit{ASI5} - \mathit{kabsSI5}\cdot \mathit{CSI5}\)
\(\frac{d[\mathtt{ASI6}]}{dt} = \mathit{kt5}\cdot \mathit{ASI5} - \mathit{kt6}\cdot \mathit{ASI6} - \mathit{kabsSI6}\cdot \mathit{CSI6}\)
\(\frac{d[\mathtt{ASI7}]}{dt} = \mathit{kt6}\cdot \mathit{ASI6} - \mathit{kt7}\cdot \mathit{ASI7} - \mathit{kabsSI7}\cdot \mathit{CSI7}\)
\(\frac{d[\mathtt{ALI1}]}{dt} = \mathit{kt7}\cdot \mathit{ASI7} - \mathit{kabsLI}\cdot \mathit{CLI1} - \mathit{kfe}\cdot \mathit{ALI1} - \frac{\mathit{VmaxLIMet2}\cdot \mathit{CLI1}}{\mathit{KmLIMet2}+\mathit{CLI1}} - \frac{\mathit{VmaxLIMet3}\cdot \mathit{CLI1}}{\mathit{KmLIMet3}+\mathit{CLI1}}\)
\(\frac{d[\mathtt{ASITissue}]}{dt} = \mathit{kabsSI1}\cdot \mathit{CSI1} + \mathit{kabsSI2}\cdot \mathit{CSI2} + \mathit{kabsSI3}\cdot \mathit{CSI3} + \mathit{kabsSI4}\cdot \mathit{CSI4} + \mathit{kabsSI5}\cdot \mathit{CSI5} + \mathit{kabsSI6}\cdot \mathit{CSI6} + \mathit{kabsSI7}\cdot \mathit{CSI7} - \frac{\mathit{QSI}\cdot \mathit{CSITissue}}{\mathit{PSI}} + \mathit{QSI}\cdot \mathit{CBlood} - \frac{\mathit{VmaxSIMet1}\cdot \frac{\mathit{CSITissue}}{\mathit{PSI}}}{\mathit{KmSIMet1}+\frac{\mathit{CSITissue}}{\mathit{PSI}}}\)
\(\frac{d[\mathtt{ALiver}]}{dt} = \mathit{kabsLI}\cdot \mathit{CLI1} + \frac{\mathit{QSI}\cdot \mathit{CSITissue}}{\mathit{PSI}} + \mathit{QL}\cdot \mathit{CBlood} - \frac{(\mathit{QL}+\mathit{QSI})\cdot \mathit{CLiver}}{\mathit{PL}} - \frac{\mathit{VmaxLMet2}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet2}+\frac{\mathit{CLiver}}{\mathit{PL}}} - \frac{\mathit{VmaxLMet3}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet3}+\frac{\mathit{CLiver}}{\mathit{PL}}} - \frac{\mathit{VmaxLMet1}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet1}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
\(\frac{d[\mathtt{ABlood}]}{dt} = - \mathit{QSI}\cdot \mathit{CBlood} - \mathit{QL}\cdot \mathit{CBlood} + \frac{(\mathit{QL}+\mathit{QSI})\cdot \mathit{CLiver}}{\mathit{PL}} - \mathit{QRest}\cdot \mathit{CBlood} + \frac{\mathit{QRest}\cdot \frac{\mathit{ARest}}{\mathit{Rest}}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{ARest}]}{dt} = \mathit{QRest}\cdot \mathit{CBlood} - \frac{\mathit{QRest}\cdot \frac{\mathit{ARest}}{\mathit{Rest}}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{AFeaces}]}{dt} = \mathit{kfe}\cdot \mathit{ALI1}\)
\(\frac{d[\mathtt{ASITissueMet1}]}{dt} = \frac{\mathit{VmaxSIMet1}\cdot \frac{\mathit{CSITissue}}{\mathit{PSI}}}{\mathit{KmSIMet1}+\frac{\mathit{CSITissue}}{\mathit{PSI}}}\)
\(\frac{d[\mathtt{ALI1Met2}]}{dt} = \frac{\mathit{VmaxLIMet2}\cdot \mathit{CLI1}}{\mathit{KmLIMet2}+\mathit{CLI1}}\)
\(\frac{d[\mathtt{ALI1Met3}]}{dt} = \frac{\mathit{VmaxLIMet3}\cdot \mathit{CLI1}}{\mathit{KmLIMet3}+\mathit{CLI1}}\)
\(\frac{d[\mathtt{ALiverMet2}]}{dt} = \frac{\mathit{VmaxLMet2}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet2}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
\(\frac{d[\mathtt{ALiverMet3}]}{dt} = \frac{\mathit{VmaxLMet3}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet3}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
\(\frac{d[\mathtt{ALiverMet1}]}{dt} = \frac{\mathit{VmaxLMet1}\cdot \frac{\mathit{CLiver}}{\mathit{PL}}}{\mathit{KmLMet1}+\frac{\mathit{CLiver}}{\mathit{PL}}}\)
Assignment rules
| variable | assignment |
|---|---|
| SI1 | VSI1 |
| SI2 | VSI2 |
| SI3 | VSI3 |
| SI4 | VSI4 |
| SI5 | VSI5 |
| SI6 | VSI6 |
| SI7 | VSI7 |
| LI1 | BW * VMB |
| SITissue | BW * VSITissuec |
| Liver | BW * VLc |
| Blood | BW * VBc |
| Rest | VRest |
| VSITissue | VSITissuec * BW |
| VL | VLc * BW |
| VB | VBc * BW |
| VSI1 | VSI |
| VSI2 | VSI |
| VSI3 | VSI |
| VSI4 | VSI |
| VSI5 | VSI |
| VSI6 | VSI |
| VSI7 | VSI |
| VRest | 0.84 * BW - VL - VB - VSITissue |
| QC | 15 * pow(BW, 0.74) |
| QL | QLc * QC |
| QSI | QSIc * QC |
| QRest | (1 - QLc - QSIc) * QC |
| Papp_in_vivo | pow(10, 0.6836 * PappCaco2_log - 0.5579) * 3600 / 10 |
| kabsSI1 | Papp_in_vivo * SASI |
| kabsSI2 | Papp_in_vivo * SASI |
| kabsSI3 | Papp_in_vivo * SASI |
| kabsSI4 | Papp_in_vivo * SASI |
| kabsSI5 | Papp_in_vivo * SASI |
| kabsSI6 | Papp_in_vivo * SASI |
| kabsSI7 | Papp_in_vivo * SASI |
| kabsLI | Papp_in_vivo * SAinb |
| SI | VSITissuec * 1000 |
| VmaxSIMet1 | VmaxSIMet1c / (1000 * 60 * S9SI * SI * BW) |
| VmaxLIMet2 | VmaxLIMet2c / 1000000 * 1000 * VMB * BW |
| VmaxLIMet3 | VmaxLIMet3c / 1000000 * 1000 * VMB * BW |
| L | VLc * 1000 |
| VmaxLMet2 | VmaxLMet2c / 1000000 * 60 * VLS9 * L * BW |
| VmaxLMet3 | VmaxLMet3c / 1000000 * 60 * VLS9 * L * BW |
| VmaxLMet1 | VmaxLMet1c / 1000 * 60 * VLS9 * L * BW |
| CSI1 | ASI1 / SI1 |
| CSI2 | ASI2 / SI2 |
| CSI3 | ASI3 / SI3 |
| CSI4 | ASI4 / SI4 |
| CSI5 | ASI5 / SI5 |
| CSI6 | ASI6 / SI6 |
| CSI7 | ASI7 / SI7 |
| CSITissue | ASITissue / SITissue |
| CLiver | ALiver / Liver |
| CBlood | ABlood / Blood |
| CLI1 | ALI1 / (VMB * BW) |
| SITissueMet1 | VmaxSIMet1 * (CSITissue / PSI) / (KmSIMet1 + CSITissue / PSI) |
| L1Met2 | VmaxLIMet2 * CLI1 / (KmLIMet2 + CLI1) |
| L1Met3 | VmaxLIMet3 * CLI1 / (KmLIMet3 + CLI1) |
| LiverMet2 | VmaxLMet2 * (CLiver / PL) / (KmLMet2 + CLiver / PL) |
| LiverMet3 | VmaxLMet3 * (CLiver / PL) / (KmLMet3 + CLiver / PL) |
| LiverMet1 | VmaxLMet1 * (CLiver / PL) / (KmLMet1 + CLiver / PL) |
Parameters
| id | name | unit | model qualifier |
|---|---|---|---|
| BW | Bodyweight | kg | http://purl.obolibrary.org/obo/PBPKO_00008 |
| VLc | Volume fraction of liver | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00078 |
| VBc | Volume fraction of blood | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00104 |
| VSITissuec | Volume fraction of small intestine tissue | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00072 |
| VMB | Feces fraction to bodyweight | dimensionless | not specified |
| VSITissue | Volume of small intestine tissue | L | not specified |
| VL | Volume of liver | L | http://purl.obolibrary.org/obo/PBPKO_00077 |
| VB | Volume of blood | L | http://purl.obolibrary.org/obo/PBPKO_00108 |
| VSI | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI1 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI2 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI3 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI4 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI5 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI6 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VSI7 | Volume of small intestine | L | http://purl.obolibrary.org/obo/PBPKO_00071 |
| VRest | Volume of rest of body | L | http://purl.obolibrary.org/obo/PBPKO_00105 |
| QSIc | Cardiac output fraction to small intestine | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00019 |
| QLc | Cardiac output fraction to liver | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00025 |
| QC | Cardiac output | L/h | http://purl.obolibrary.org/obo/PBPKO_00013 |
| QL | Cardiac output to liver | L/h | http://purl.obolibrary.org/obo/PBPKO_00024 |
| QSI | Cardiac output to small intestine | L/h | http://purl.obolibrary.org/obo/PBPKO_00018 |
| QRest | Cardiac output to rest of body | L/h | http://purl.obolibrary.org/obo/PBPKO_00050 |
| PL | Partition coefficient blood-liver | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00577 |
| PSI | Partition coefficient blood-small intestine | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00574 |
| PRest | Partition coefficient blood- rest body | dimensionless | http://purl.obolibrary.org/obo/PBPKO_00585 |
| ksto | stomach emptying rate | /h | not specified |
| kt1 | Transfer rate to next compartment within the intestine | /h | not specified |
| kt2 | Transfer rate to next compartment within the intestine | /h | not specified |
| kt3 | Transfer rate to next compartment within the intestine | /h | not specified |
| kt4 | Transfer rate to next compartment within the intestine | /h | not specified |
| kt5 | Transfer rate to next compartment within the intestine | /h | not specified |
| kt6 | Transfer rate to next compartment within the intestine | /h | not specified |
| kt7 | Transfer rate to next compartment within the intestine | /h | not specified |
| kfe | Transfer rate to feces | /h | http://purl.obolibrary.org/obo/PBPKO_00236 |
| PappCaco2_log | logaritmic Papp caco 2 value | cm/h | not specified |
| Papp_in_vivo | effective Papp Caco 2 | not specified | not specified |
| SASI | Surface area per intestinal compartment | dm^2 | http://purl.obolibrary.org/obo/PBPKO_00010 |
| kabsSI1 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| kabsSI2 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| kabsSI3 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| kabsSI4 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| kabsSI5 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| kabsSI6 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| kabsSI7 | Absorption rate constant | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| SAinb | Surface are of large intestine | dm^2 | http://purl.obolibrary.org/obo/PBPKO_00010 |
| kabsLI | Absorption rate from large intestine | L/h | http://purl.obolibrary.org/obo/PBPKO_00142 |
| MW | Molecular weight | g/mol | http://purl.obolibrary.org/obo/PBPKO_00127 |
| S9SI | Scaling factor small intestinal S9 protein yield | mg/g | not specified |
| SI | Small intestine to bodyweight | g/kg | http://purl.obolibrary.org/obo/PBPKO_00072 |
| VmaxSIMet1c | Vmax constant | not specified | http://purl.obolibrary.org/obo/PBPKO_00212 |
| VmaxSIMet1 | Vmax | not specified | http://biomodels.net/SBO/SBO_0000027 |
| KmSIMet1 | Kinetic constant | umol/L | http://biomodels.net/SBO/SBO_0000027 |
| VmaxLIMet2c | Vmax constant | not specified | http://purl.obolibrary.org/obo/PBPKO_00212 |
| VmaxLIMet3c | Vmax constant | not specified | http://purl.obolibrary.org/obo/PBPKO_00212 |
| VmaxLIMet2 | Vmax | not specified | http://biomodels.net/SBO/SBO_0000027 |
| VmaxLIMet3 | Vmax | not specified | http://biomodels.net/SBO/SBO_0000027 |
| KmLIMet2 | Kinetic constant | umol/L | http://biomodels.net/SBO/SBO_0000027 |
| KmLIMet3 | Kinetic constant | umol/L | http://biomodels.net/SBO/SBO_0000027 |
| VLS9 | Scaling factor liver S9 protein yield | mg/g | not specified |
| L | Volume fraction of liver | g/kg | http://purl.obolibrary.org/obo/PBPKO_00078 |
| VmaxLMet2c | Vmax constant | not specified | http://purl.obolibrary.org/obo/PBPKO_00214 |
| VmaxLMet3c | Vmax constant | not specified | http://purl.obolibrary.org/obo/PBPKO_00214 |
| VmaxLMet1c | Vmax constant | not specified | http://purl.obolibrary.org/obo/PBPKO_00214 |
| VmaxLMet2 | Vmax | not specified | http://biomodels.net/SBO/SBO_0000027 |
| VmaxLMet3 | Vmax | not specified | http://biomodels.net/SBO/SBO_0000027 |
| VmaxLMet1 | Vmax | not specified | http://biomodels.net/SBO/SBO_0000027 |
| KmLMet2 | Kinetic constant | umol/L | http://biomodels.net/SBO/SBO_0000027 |
| KmLMet3 | Kinetic constant | umol/L | http://biomodels.net/SBO/SBO_0000027 |
| KmLMet1 | Kinetic constant | umol/L | http://biomodels.net/SBO/SBO_0000027 |
| CSI1 | Concentration in small intestine | mg/L | not specified |
| CSI2 | Concentration in small intestine | mg/L | not specified |
| CSI3 | Concentration in small intestine | mg/L | not specified |
| CSI4 | Concentration in small intestine | mg/L | not specified |
| CSI5 | Concentration in small intestine | mg/L | not specified |
| CSI6 | Concentration in small intestine | mg/L | not specified |
| CSI7 | Concentration in small intestine | mg/L | not specified |
| CSITissue | Concentration in small intestine tissue | mg/L | not specified |
| CLiver | Concentration in liver | mg/L | http://purl.obolibrary.org/obo/PBPKO_00539 |
| CBlood | Concentration in blood | mg/L | http://purl.obolibrary.org/obo/PBPKO_00301 |
| CLI1 | Concentration in large intestine | mg/L | not specified |
| SITissueMet1 | not specified | not specified | not specified |
| L1Met2 | not specified | not specified | not specified |
| L1Met3 | not specified | not specified | not specified |
| LiverMet2 | not specified | not specified | not specified |
| LiverMet3 | not specified | not specified | not specified |
| LiverMet1 | not specified | not specified | not specified |