Loizou
Overview
| key | value |
|---|---|
| Modelled species/orgamism(s) | not specified |
| Model chemical(s) | not specified |
| Input route(s) | 1 (oral) |
| Time resolution | not specified |
| Amounts unit | not specified |
| Volume unit | not specified |
| Number of compartments | 5 |
| Number of species | 8 |
| Number of parameters | 38 (32 external / 6 internal) |
Diagram
Compartments
| id | name | unit | model qualifier |
|---|---|---|---|
| Stomach | stomach | not specified | not specified |
| Liver | liver | not specified | not specified |
| Plasma | blood plasma | not specified | http://purl.obolibrary.org/obo/PBPKO_00488 |
| Gut | gut | not specified | http://purl.obolibrary.org/obo/PBPKO_00477 |
| Rest | rest-of-body | not specified | http://purl.obolibrary.org/obo/PBPKO_00450 |
Species
| id | name | unit | model qualifier |
|---|---|---|---|
| AStomach | not specified | not specified | not specified |
| ALiver | amount of chemical in liver | not specified | http://purl.obolibrary.org/obo/PBPKO_00497 |
| APlasma | amount of chemical in plasma | not specified | http://purl.obolibrary.org/obo/PBPKO_00502 |
| AGut | amount of chemical in gut | not specified | http://purl.obolibrary.org/obo/PBPKO_00496 |
| ARest | amount of chemical in rest-of-body | not specified | http://purl.obolibrary.org/obo/PBPKO_00501 |
| AGutMet1 | not specified | not specified | not specified |
| ALiverMet1 | not specified | not specified | not specified |
| ALiverMet2 | not specified | not specified | not specified |
Transfer equations
| id | from | to | equation |
|---|---|---|---|
| _J0 | AStomach | AGut | ksto * AStomach |
| _J1 | AStomach | ALiver | k0 * AStomach |
| _J2 | AGut | ALiver | kabs * AGut |
| _J3 | AGut | AGutMet1 | VmaxGMet1 * CGut * fu / (CGut * fu + KmGMet1) |
| _J4 | APlasma | ALiver | QL * CPlasma * fu |
| _J5 | ALiver | APlasma | QL * fu * CLiver / PL |
| _J6 | APlasma | ARest | QRest * CPlasma * fu |
| _J7 | ARest | APlasma | QRest * fu * CRest / PRest |
| _J8 | ALiver | ALiverMet1 | VmaxLMet1 * CLiver * fu / (CLiver * fu + KmLMet1) |
| _J9 | ALiver | ALiverMet2 | VmaxLMet2 * CLiver * fu / (CLiver * fu + KmLMet2) |
ODEs
\(\frac{d[\mathtt{AStomach}]}{dt} = - \mathit{ksto}\cdot \mathit{AStomach} - \mathit{k0}\cdot \mathit{AStomach}\)
\(\frac{d[\mathtt{ALiver}]}{dt} = \mathit{k0}\cdot \mathit{AStomach} + \mathit{kabs}\cdot \mathit{AGut} + \mathit{QL}\cdot \mathit{CPlasma}\cdot \mathit{fu} - \frac{\mathit{QL}\cdot \mathit{fu}\cdot \mathit{CLiver}}{\mathit{PL}} - \frac{\mathit{VmaxLMet1}\cdot \mathit{CLiver}\cdot \mathit{fu}}{\mathit{CLiver}\cdot \mathit{fu}+\mathit{KmLMet1}} - \frac{\mathit{VmaxLMet2}\cdot \mathit{CLiver}\cdot \mathit{fu}}{\mathit{CLiver}\cdot \mathit{fu}+\mathit{KmLMet2}}\)
\(\frac{d[\mathtt{APlasma}]}{dt} = - \mathit{QL}\cdot \mathit{CPlasma}\cdot \mathit{fu} + \frac{\mathit{QL}\cdot \mathit{fu}\cdot \mathit{CLiver}}{\mathit{PL}} - \mathit{QRest}\cdot \mathit{CPlasma}\cdot \mathit{fu} + \frac{\mathit{QRest}\cdot \mathit{fu}\cdot \mathit{CRest}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{AGut}]}{dt} = \mathit{ksto}\cdot \mathit{AStomach} - \mathit{kabs}\cdot \mathit{AGut} - \frac{\mathit{VmaxGMet1}\cdot \mathit{CGut}\cdot \mathit{fu}}{\mathit{CGut}\cdot \mathit{fu}+\mathit{KmGMet1}}\)
\(\frac{d[\mathtt{ARest}]}{dt} = \mathit{QRest}\cdot \mathit{CPlasma}\cdot \mathit{fu} - \frac{\mathit{QRest}\cdot \mathit{fu}\cdot \mathit{CRest}}{\mathit{PRest}}\)
\(\frac{d[\mathtt{AGutMet1}]}{dt} = \frac{\mathit{VmaxGMet1}\cdot \mathit{CGut}\cdot \mathit{fu}}{\mathit{CGut}\cdot \mathit{fu}+\mathit{KmGMet1}}\)
\(\frac{d[\mathtt{ALiverMet1}]}{dt} = \frac{\mathit{VmaxLMet1}\cdot \mathit{CLiver}\cdot \mathit{fu}}{\mathit{CLiver}\cdot \mathit{fu}+\mathit{KmLMet1}}\)
\(\frac{d[\mathtt{ALiverMet2}]}{dt} = \frac{\mathit{VmaxLMet2}\cdot \mathit{CLiver}\cdot \mathit{fu}}{\mathit{CLiver}\cdot \mathit{fu}+\mathit{KmLMet2}}\)
Assignment rules
| variable | assignment |
|---|---|
| VRest | 0.84 * BW - VL - VPlasma - VG |
| CLiver | ALiver / Liver |
| CPlasma | APlasma / Plasma |
| CPlasma_Total | CPlasma / fu |
| CGut | AGut / Gut |
| CRest | ARest / Rest |
Initial assignments
| variable | assignment |
|---|---|
| Liver | VL |
| Plasma | VPlasma |
| Gut | VG |
| Rest | VRest |
| VL | VLc * BW |
| VPlasma | VPlasmac * BW |
| VG | VGc * BW |
| QC | 20 * pow(BW, 0.75) |
| QL | QLc * QC |
| QG | QGc * QC |
| QRest | (1 - QLc - QGc) * QC |
| k0 | k0C * pow(BW, -0.25) |
| ksto | kstoC * pow(BW, -0.25) |
| kabs | kabsC * pow(BW, -0.25) |
| VmaxGMet1 | 22750 / 1000 * pow(BW, 0.75) |
| VmaxLMet1 | 680095.6 / 1000 * pow(BW, 0.75) |
| VmaxLMet2 | 11657 / 1000 * pow(BW, 0.75) |
Parameters
| id | name | unit | model qualifier |
|---|---|---|---|
| BW | body weight | not specified | http://purl.obolibrary.org/obo/PBPKO_00008 |
| VLc | not specified | not specified | not specified |
| VPlasmac | not specified | not specified | not specified |
| VGc | not specified | not specified | not specified |
| VL | not specified | not specified | not specified |
| VPlasma | not specified | not specified | not specified |
| VG | not specified | not specified | not specified |
| VRest | not specified | not specified | not specified |
| QC | not specified | not specified | not specified |
| QLc | not specified | not specified | not specified |
| QGc | not specified | not specified | not specified |
| QL | not specified | not specified | not specified |
| QG | not specified | not specified | not specified |
| QRest | not specified | not specified | not specified |
| Hct | not specified | not specified | not specified |
| fu | not specified | not specified | not specified |
| k0C | not specified | not specified | not specified |
| k0 | not specified | not specified | not specified |
| kstoC | not specified | not specified | not specified |
| ksto | not specified | not specified | not specified |
| kabsC | not specified | not specified | not specified |
| kabs | not specified | not specified | not specified |
| VmaxGMet1C | not specified | not specified | not specified |
| VmaxGMet1 | not specified | not specified | not specified |
| KmGMet1 | not specified | not specified | not specified |
| VmaxLMet1C | not specified | not specified | not specified |
| VmaxLMet1 | not specified | not specified | not specified |
| KmLMet1 | not specified | not specified | not specified |
| VmaxLMet2C | not specified | not specified | not specified |
| VmaxLMet2 | not specified | not specified | not specified |
| KmLMet2 | not specified | not specified | not specified |
| PL | not specified | not specified | not specified |
| PRest | not specified | not specified | not specified |
| CLiver | not specified | not specified | not specified |
| CPlasma | not specified | not specified | not specified |
| CPlasma_Total | not specified | not specified | not specified |
| CGut | not specified | not specified | not specified |
| CRest | not specified | not specified | not specified |