Christensen
Notes
BPA PBPK (adult) after Christensen et al. 2013 2-compartment model
Overview
| key |
value |
| Modelled species/orgamism(s) |
not specified |
| Model chemical(s) |
not specified |
| Input route(s) |
no routes detected |
| Time resolution |
not specified |
| Amounts unit |
not specified |
| Volume unit |
not specified |
| Number of compartments |
3 |
| Number of species |
3 |
| Number of parameters |
7 (4 external / 3 internal) |
Diagram
Compartments
| id |
name |
unit |
model qualifier |
| Stomach |
not specified |
not specified |
not specified |
| Blood |
not specified |
not specified |
not specified |
| Bladder |
not specified |
not specified |
not specified |
Species
| id |
name |
unit |
model qualifier |
| ASt |
not specified |
not specified |
not specified |
| ABlood |
not specified |
not specified |
not specified |
| AExcr |
not specified |
not specified |
not specified |
Transfer equations
| id |
from |
to |
equation |
| _J0 |
ASt |
ABlood |
F1 * k1 * ASt |
| _J1 |
ABlood |
AExcr |
F2 * k2 * ABlood |
ODEs
\(\frac{d[\mathtt{ASt}]}{dt} = - \mathit{F1}\cdot \mathit{k1}\cdot \mathit{ASt}\)
\(\frac{d[\mathtt{ABlood}]}{dt} = \mathit{F1}\cdot \mathit{k1}\cdot \mathit{ASt}
- \mathit{F2}\cdot \mathit{k2}\cdot \mathit{ABlood}\)
\(\frac{d[\mathtt{AExcr}]}{dt} = \mathit{F2}\cdot \mathit{k2}\cdot \mathit{ABlood}\)
Assignment rules
| variable |
assignment |
| Blood |
VD * BW |
| k1 |
0.9 / 60 |
| k2 |
0.9 / 60 |
| CBlood |
ABlood / Blood |
Parameters
| id |
name |
unit |
model qualifier |
| BW |
not specified |
not specified |
not specified |
| VD |
not specified |
not specified |
not specified |
| F1 |
not specified |
not specified |
not specified |
| F2 |
not specified |
not specified |
not specified |
| k1 |
not specified |
not specified |
not specified |
| k2 |
not specified |
not specified |
not specified |
| CBlood |
not specified |
not specified |
not specified |